A portable non-invasive microwave-based head imaging modality using a firm metamaterial-loaded unidirectional antenna for stroke detection and localization is presented in this chapter. The device is based on detecting the difference in dielectric properties between abnormal and healthy tissue. This chapter explains the advancements in hardware and software, as well as the difficulties during the transition into clinical practice, along with the scanning method. However, it is not approved for clinical practice till now. Some recently published case reports successfully detect, localize, and classify strokes, with high accuracy and positive user feedback, paving the way for its potential integration into routine clinical practice. The studies suggest that the development of such a scanner could transform the management of acute stroke by facilitating early treatment and triage at specialized stroke centres. The rapid imaging capability allows for quicker decision-making in emergency settings, potentially leading to improved clinical outcomes for patients suffering from strokes.