Ochrobactrum anthropi (O. anthropi) is an aerobic, oxidase-positive, urease-positive, Gram-negative, motile, non-lactose-fermenting bacillus previously called as “Achromobacter group Vd”. Ochrobactrum spp. belongs to the Brucellaceae family. The organism has the potential to colonize wide variety of habitats. The genus Ochrobactrum currently comprises 9 species; to date, only 3 species, O. anthropi, O. intermedium, and O. pseudintermedium, have been reported to occur in clinical specimens. Most cases of human disease due to this pathogen are associated with central venous catheter line infection. However, this organism has also be seen as a cause of infective endocarditis, pancreatic abscess, puncture wound osteochondritis, endophthalmitis, urinary tract infection, meningitis, pelvic abscess, and osteomyelitis. Infection is most commonly seen in immunocompromised patients, such as those with debilitating illnesses or malignancy. Opportunistic infections and nosocomial outbreaks of infections with O. anthropi are being increasingly reported. Of the clinically relevant species, O. anthropi is becoming increasingly demonstrated as a potentially problematic, opportunistic, and nosocomial pathogen. We have detected a case of Ochrobactrum anthropi from blood specimen in a female patient admitted in ICU.