Cushing’s syndrome is a multifaceted endocrine disorder characterized by chronic hypercortisolism, often stemming from excessive glucocorticoid exposure, which can be endogenous or exogenous. This syndrome affects multiple physiological systems, manifesting as central obesity, “moon face,” muscle weakness, skin fragility, and immunosuppression. Beyond its well-documented systemic impacts, emerging research has highlighted significant oral health complications associated with Cushing’s syndrome, particularly regarding bone density, structural development, and tooth eruption. Dental professionals are increasingly encountering complex cases where the disease’s systemic nature intersects with dental anomalies, necessitating an integrated approach to treatment. This chapter introduces a case study of a 22-year-old female patient with Cushing’s syndrome who sought a second opinion for the replacement of a missing maxillary canine. Given her condition, the recommendation for a Zirconia bridge over an implant reflected careful consideration of her systemic health. Through an in-depth analysis of her treatment journey, medical history, and the challenges faced in conventional dental practices, this chapter underscores the necessity for interdisciplinary awareness and tailored therapeutic approaches when managing dental health in patients with systemic endocrine disorders like Cushing’s syndrome.