Magnetomotive ultrasound (MMUS) is a new emerging technique that uses superparamagnetic nanoparticles of iron oxide (SPIONs) as the primary contrast agent. Several potential advantages and drawbacks of MRI and ultrasound leads to the new approach as a hybrid imaging technique. MMUS can detect displacement of these nanoparticles and its distribution throughout the body without causing toxicity to the body. While use of time-varying magnetic field, excitations can be observed within the sub-micrometre range by ultrasound, which gives subsequent results in animal studies. Several in vivo examinations have been demonstrated on human tissues as well in recently published studies, which shows its potential as a hybrid imaging technique. As a result, much earlier diagnosis is possible which allows effective therapy planning. The goal of ongoing work is to evolve a merged real-time implementation in clinical field, which can make MMUS a strong potential nominee for molecular ultrasonography technique. This chapter has covered various proposed configurations of this modality, as well as developments and futuristic approaches.