Antimicrobial resistance (AMR) poses a significant risk to public health worldwide; in 2019, bacterial AMR was linked to almost 5 million fatalities. The development of new antimicrobial therapeutic strategies, improved infection prevention and control measures, AMR surveillance, antimicrobial stewardship, enhanced knowledge of mechanisms and drivers at the individual and population levels, and strengthened international policies and funding are all components of a comprehensive and integrated strategy to combat AMR. This Review offers a succinct overview of AMR in this quickly developing subject, covering epidemiology, evolution, and underlying mechanisms (mostly those about last-line or newer generation antibiotics). AMR surveillance, antibiotic availability, antimicrobial stewardship, infection prevention and control strategies, and new non-antibiotic treatment modalities. Antimicrobial susceptibility testing, AMR surveillance, antimicrobial stewardship, diagnostics, and antimicrobial drug research and discovery are among the possible applications of AI in combating AMR that are included in the Review. This review emphasizes how critical it is to address AMR's worldwide impacts and quickly develop pertinent technologies in this ever-evolving industry.