Purpose: This chapter examines the transformative impact of digitization on supply chain management (SCM), with a focus on how advanced technologies streamline operations, improve decision-making processes, and promote sustainability. The study highlights the implications of integrating tools such as artificial intelligence (AI), blockchain, the Internet of Things (IoT), and big data analytics into supply chain operations. Emphasis is placed on their contributions to enhancing efficiency, agility, and resilience. Design/Methodology/Approach: A comprehensive review and analytical approach is employed to assess the adoption and implementation of digital technologies in SCM. Insights are drawn from academic literature, industry reports, and real-world case studies spanning multiple industries. The study combines qualitative evaluations of successful implementations with quantitative data to demonstrate performance enhancements driven by digitization. A comparative framework is utilized to showcase industry-specific applications and best practices. Findings: The analysis reveals that digitization significantly improves supply chain visibility, operational efficiency, and customer satisfaction. Notable outcomes include faster decision-making facilitated by predictive analytics, cost reductions through automation, and enhanced transparency via blockchain technology. Furthermore, the use of IoT devices supports real-time monitoring, minimizing disruptions and ensuring smoother operations. Despite these benefits, challenges such as high initial implementation costs, data security concerns, and the need for workforce skill development persist. Limitations: This study primarily relies on secondary data, which may not fully capture the latest trends or real-time developments in supply chain digitization. Additionally, while the analysis encompasses diverse industries, it may not fully address specific regional or sectoral nuances. Future studies could employ primary data collection and longitudinal analyses to provide deeper insights into the evolving dynamics of digital transformation in SCM. Implications: For practitioners, this chapter offers practical guidance on leveraging digital tools to optimize supply chain performance. Policymakers and organizational leaders can utilize these findings to prioritize investments in technology and workforce upskilling. The chapter also provides academics with a foundation for exploring new research avenues, particularly those examining the intersection of digitization and sustainability in supply chains. Originality: This chapter presents a holistic perspective on the role of digitization in SCM, bridging theoretical concepts with practical applications. It provides a roadmap for organizations seeking to enhance their supply chain processes through digital transformation. Additionally, it underscores the relationship between technology adoption and sustainability goals, highlighting the importance of aligning digital strategies with broader organizational objectives.