In wake of developmental needs and environmental stress signals, cell death is a necessity in all the organisms. Regulated cell demise is carried out by Programmed cell death which is a genetically controlled pathway. PCD in animals is carried out by apoptosis where enzymes called caspases have a major role to play in both extrinsic and intrinsic pathways. PCD in plants vary to some extent from apoptosis in animals as seen in absence of phagocytosis in plants. But there are certain similarities such as presence of caspase like enzymes and membrane blebbing in plant cells. Moreover, introduction of proapoptotic and antiapoptotic genes in plants are shown to increase or suppress cell death in plants. Vacuoles have a critical role in cell death in plants. Based on the morphology of the cell and pathways, PCD can be destructive and non-destructive in plants. In Non-destructive type PCD, vacuolar membrane and plasma membrane of the cell fuses and hydrolases are discharged into extracellular space while in destructive type PCD, vacuolar membrane bursts and releases its contents into cytosol and such PCD is initiated by Vacuolar Processing Enzyme/VPE. Autophagy is another mechanism of PCD commonly seen in plants which is driven by Autophagy related genes (ATG). Necrosis is a form of cell death seen in response to invasion of pathogen in plant cell and here rapid cell death occurs to prevent spread of the pathogen and also causes inflammatory response. In this chapter, various mechanisms of PCD that occurs in plant cells along with the genes that drive them are mentioned and similarities and dissimilarities of PCD in plant and animal cells are discussed.