Vegetables are generally sensitive to environmental extremes, and thus high temperatures and limited soil moisture are the major causes of low yields in the tropics and will be further magnified by climate change. The response of plants to environmental stresses depends on the plant developmental stage and the length and severity of the stress. Plants may respond similarly to avoid one or more stresses through morphological or biochemical mechanisms. Plant breeders need to translate these findings into stress tolerant crop varieties by using all tools available that include germplasm screening, marker-assisted selection, plant transformation, and conventional breeding methods. Molecular biology and genomic investigations lead to a better understanding of the structural organization and functional properties of genetic variation for stress-related traits, allow gene-based selection through identification of molecular markers and high-throughput genotyping techniques, and increase the gene pool available, including new sources of stress-tolerant traits or transgenes. The genetically complex responses to abiotic stresses are multigenic and thus more difficult to control and engineer. Plant engineering strategies for abiotic stress tolerance rely on the expression of genes that are involved in signaling and regulatory pathways or genes that encode proteins conferring stress tolerance or enzymes present in pathways leading to the synthesis of functional and structural metabolites. Vegetable crops are currently exposed to multiple abiotic stresses because of ongoing climate change. Abiotic stresses such as drought, extreme temperatures, salinity, and nutrient deficiencies are causing increasing losses in terms of yield and product quality. The Vegetable sector is therefore searching for innovative and sustainable agronomic tools to enhance crop tolerance towards these unfavorable conditions