Seeds play very important role in input technology in horticulture sector due to it’s easy handling and transporting from one place to another. Therefore, in horticulture, demand and supply of quality seeds hold the center position. Further the quality of seeds is a determinant factor for the yield of particular crop. Hence, the seeds of high quality are always in demand. The crop growers as well as the kitchen garden growers always have faced some problems, associated with the seeds, like more time taken for germination and less germination percentage leading to yield loss. Seed germination and uniform plant stand in field are of most critical stages of crop growth that determine the final yield. Seed priming is an age-old and simple but effective technique to enhance germination percentage to achieve uniform plant stand and better yield in a wide range of environmental conditions. Seed priming is a controlled hydration of seeds to a level that allow pre-germinative metabolic activity to continue, but interrupt the emergence of the radicle. It improves seed performance, ensures uniformity and better establishment, enhances the yield in diverse environments, greater tolerance to environmental stress and helps to overcome dormancy. Seed priming technique is innovative, cheap, and easy to apply at farmer’s field conditions. Also, many successful case studies were reported regarding seed priming in amelioration of biotic and abiotic stress till date. But, until now, complete molecular mechanism of seed priming during various stresses is unknown. Therefore, future goals of agricultural scientists are to identify novel genes, proteins, and transcription factors, which are expressed during stresses, and to improve our knowledge regarding crop behaviour under drastic climatic change scenario. Then only, we can achieve our need of food security for everyone in near future