An omic approach involves genomics, transcriptomics, proteomics, metabolomics, and beyond, have revolutionized research in fruit crops. These techniques allow comprehensive analysis of genetic, molecular, and biochemical aspects, facilitating advancements in breeding, disease resistance, and fruit quality improvement. By integrating vast datasets, omic approaches offer insights into complex biological processes and interactions within fruit crops, promising sustainable agricultural practices and enhanced nutritional profiles. This chapter underscores the transformative impact of omics in fruit crop research, highlighting their pivotal role in addressing global food security challenges.