There are many kinds of native plants around us. Most of them have medicinal properties. Medicinal plants are being used from ancient without knowing about their active elements. Herbs are occupied the top source of novel drug with immunomodulatory effect and antimicrobial activity. Ayurveda is better than allopathy. Because, Ayurveda remedies are close to natural science. Herbal plants do not have any side effects like allopathic medicine. Ayurveda chiefly contains natural products such as fruits, vegetables, spices. Hence, they help in treating many of the diseases without causing any side effects. The purpose of this article is to explain the immunomodulatory effect of various herbal plants and their benefits.