The various side effects of the allopathic medicines have driven the minds of scientists and researchers to shift their focus on the pharmacological characteristics of herbal plants. The present review explores the therapeutic potential of a perennial herb, Boerhavia diffusa that has been used in the Ayurvedic and Unani system of medicine. Numerous medicinal properties including anti-oxidant, anti-inflammatory, anti-hyperglycemic, anti-nephrotoxic, cardiotonic, anti-cancer property have been found to be present in the plant that has been primarily attributed to the presence of phytochemical constituents like the alkaloid punarnavine. Thus, the possession of a number of phytoconstituents isolated from primarily the ethanolic and the methanolic extract confers the multifaceted character of being effective against a number of ailments. However, extrapolated studies on the medicinal characteristics of the crude extracts of the herb as well as the isolated compounds are required that might be useful in exploiting the curative property to a whole new extent and as such the herbal treatment of various human diseases like diabetes, renal disease and cancer might thereby reduce the load on allopathic medicine with lesser side effects and present a holistic approach to life, stability of mind, body and environment and stress on health quality instead of disease.