Plants are used medicinally in different countries and are a source of many potent and powerful drugs. Various plants of Acacia species were claimed to possess traditional medicinal activities. Different parts of plant have different phytochemical constitution and different pharmacological action. Different species of Acacia have been reported, but only a few of these find medicinal importance out of which the prominent ones are Acacia nilotica, Acacia polyacantha, Acacia leucocephala and Acacia farnesiana. In light of this, the present review aims at exploring current scientific findings on the various plants of this specie. The present review mainly covers some of the important medicinal plants belonging to the Acacia spp. with special attention towards their various traditional uses, chemical constituents and medicinal properties.