Human ailments have traditionally been treated with herbs and their preparations. Widely regarded as a source of novel and beneficial medications, botanical extracts. Around 62% of commercially accessible medications have organic product origins, according to Cragg's analysis. Manjistha, scientifically known as Rubia cordifolia, is a branching climber with tiny, greenish-white blooms and a clump of ovoid, meaty, purple fruits. Its roots have bark that is reddish-brown and used to make red dye. The root of this plant has therapeutic properties and thrives in mountainous areas. Ayurveda, the oldest medicinal system in the world with origins in India, considers manjistha as being among the most precious herbs. The plant is classified as varnya, or that which enhances beauty, jvarahara, or that which lowers fever, and visaghna, or that which detoxifies, by the legendary doctor and sage Charaka. Additionally, it is a well-known rasayana, or rejuvenator. Manjistha has been referred to as pittasamsamana, or that which calms the pitta doshas, by some other renowned sage, Sushruta. Ayurveda holds that only when the three life forces, or doshas, that comprise everyone’s constitution are perfectly balanced can a person have optimum health. Vata, Pitta, and Kapha are the three doshas, and any unbalance leads to sickness. Manjistha is best able to properly combat Pitta dosha imbalances. This study aims to bring together the knowledge that is currently accessible on its historical applications, pharmacological, and biological activity.