Potato (Solanum tuberosum L.) possesses a significant place among major tuber crops. Owing to its demand the production must increase. This is possible by increasing crop productivity through application of technologies and one of course is the nutrient management. Like other crops, both macro and micronutrients are required for proper growth and development of potato crop. Studies conducted across the globe indicate that application of nutrients both in isolation and in combination has significant impact on yields and potato quality. In general, though there seem to be a variability in results in terms of optimum doses of fertilizers for higher yield and quality in different regions but the trends do match among many studies. Micronutrients have received very less attention of growers in the past. Due to continuous removal by crops and adverse edaphic factors, micronutrient deficiencies are now emerging as major challenge in sustaining potato yields and quality. Even disproportionate supply of plant nutrients results into yield penalty. Plant growth, development and even the defence mechanism against both biotic and abiotic stresses may have direct or indirect relation with crop nutrition and blending organic and biological sources of nutrients becomes crucial for the purpose. In this chapter an attempt has been made to cover major aspects of nutrient management in potato in light of the research findings across different parts of the world under different ecologies.