The production of potato seed using conventional methods has not been successful in preventing or minimising the accumulation of infections, which has resulted in lower crop yields and potato seed of lower quality. After being cleaned through meristem culture and tuberization induction in an aeroponics system, plants quickly generate high-quality potato seed tubers that are pathogen-free. Potato seed tubers can be multiplied further using aeroponics, which works well with tissue culture (micropropagation) since it quickly clones minitubers and eliminates many labour-intensive procedures involved in using plantlets directly from tissue culture in the field beyond the flask stage. Without the need for acclimatisation to such settings, mini tubers from air-rooted plants are planted straight in the field. This technology, like micropropagation, has the potential to boost income and lower the cost of producing high-quality seed, making it more affordable for growers in impoverished nations where the use of subpar seed tubers severely restricts potato production. Because it uses plant seeds from tissue culture, potato seed manufacturing using aeroponic technology can yield a huge number of seeds while also being healthy. Unfortunately, it hasn't been well researched and documented how the quality of aeroponic seeds produced to become the subsequent seeds (growth capacity) is determined. This review sheds light on how plant tissue culture and aeroponics could revolutionise the way potato seeds are produced in agricultural settings.