Gwalior Chambal region of Northern part of Madhya Pradesh, India is home of numerous plant species. The agro-climatic conditions prevailing in the region provide an ideal habitat for the natural growth of a variety of plants, which provide raw materials for pharmaceutical, photochemical, food, flavoring and cosmetic industries. The paper provides information on various medicinal plants used by the tribal regions of Madhya Pradesh, India, for the treatment of various diseases. Traditional medicine remains an integral part of the health system in this area. Medicinal plants of forest origin hold great promise to enhance the health and livelihoods of the forest dwellers. Plants also play a great role in enhancing the economy of folk people.