The aim of the present research is to verify the effectiveness of a hybrid control strategy. The hybrid control consists of a seismic isolation device and non-traditional tuned mass damper (TMD). In the evaluation, the study was conducted for structures with a ten-story reinforced concrete buildings exposed to various far-field and near-field earthquake records. The structure is modeled as a system with two degrees of freedom. One degree of freedom reflects the main structure and the other degree of freedom represents the auxiliary system, and the Bouc-Wen model is used to describe the hysteresis behavior of the base insulator. The results of the study clearly confirmed that the response of high-rise buildings during earthquakes could be significantly reduced using base isolation devices and TMDs. Buildings analyzed in the study, the application of TMD alone resulted in a reduction not larger than 20%, as compared to the response without any system. On the other hand, the response of buildings equipped with only base isolation devices was reduced by more than 35% under different ground motions. However, the largest reductions (larger than 50%) were obtained for the cases when both control systems (base isolation and TMDs) were used simultaneously.