Field investigations were conducted in the Northern block, Agricultural Research Station, Bhavanisagar, Erode during rabi 2017-18 & 2018-19 and summer 2018 & 2019 to assess the influence of moisture stress management practices in different irrigation regimes in maize. The experiment was laid out in split plot design with three replications comprised of four irrigation regimes as main factor based on IW/CPE ratio of 1.0 (I1.0), 0.8(I0.8), 0.6 (I0.6) and 0.4 (I0.4) and four moisture stress management treatments viz., foliar application of pink pigmented facultative methylobacteria 1% (FPPFM), Brassinolide 0.1 ppm (FBr), Silicic acid 0.2% (FSl) and control (FC) as a sub factor. Foliar application was given on 25 and 45 DAS for each treatment in the sub plot. Maize cultivar CO(H)M 6 was used as a test variety spaced with 60x25cm. Results revealed that growth parameters, physiological parameter, nutrient uptake and yield attributes were significantly higher in the irrigation regimes of IW/CPE 1.0 and 0.8. Substantially higher net return and benefit: cost ratio were observed in IW/CPE 0.8. Among the moisture stress management practices, foliar application of pink pigmented facultative methylobacteria 1% on 25 and 45 DAS produced substantially growth parameters, physiological parameter, root growth, nutrient uptake and yield attributes. In water deficit condition, moderate stress (IW/CPE 0.6) with foliar application of pink pigmented facultative methylobacteria 1% on 25 and 45 DAS produced moderate growth parameters, physiological parameter, nutrient uptake, yield attributes and net return which was comparable with normal irrigation (IW/CPE 1.0 and 0.8). Based on the experimental results, it can be concluded that that irrigating at IW/CPE ratio of 0.8 with no moisture stress management practice is ideal for obtaining higher yield and economic returns at normal condition. Under water scarcity condition irrigating at IW/CPE 0.6 coupled with foliar application of PPFM 1% on 25 and 45 DAS was found to be suitable for obtaining optimum yield and economic return with higher water use efficiency and water productivity.