Drought is considered as one of the most threats to wheat growers particularly in the regions of rainfed agriculture throughout the world. Therefore, this is a big challenge to breeders that must be given top priority for developing drought tolerant/resistant wheat varieties. So far, wheat breeders are exploring the underlying mechanisms of drought tolerance. Crop demonstrate various morphological, physiological, biochemical and molecular responses to tackle drought stress. Understanding the genetics of drought tolerance and selection methods give us the possibility to develop a drought tolerant/resistant varieties by combining both the conventional and molecular approaches. Progress is, however, hampered because drought tolerance is a complex trait that is controlled by many genes and its full expression is affected by the environment. An association between markers and traits can reduce the influence of the environment which is a major hindrance in conventional selection of complex quantitative traits.