Rice require more water for sustained growth, development and orientation of physiological process because it is a semi-aquatic plant. In rainfed regions across the world, drought is a significant problem that restricts rice production. Therefore, rice production is severely affected by drought stress. Drought stress affects rice at morphological (reduced germination, plant height, number of tillers, plant biomass, many various root and leaf traits), physiological (reduced water use efficiency), relative water content (RWC), stomatal conductance, chlorophyll content, photosystem-II activity, photosynthesis, transpiration and membrane stability), biochemical (accumulation of osmo-protectant viz., proline, sugars, polyamines and antioxidants content) and molecular (change expression of genes which encode transcription factors and stress tolerance related proteins) levels and thereby affects its yield. The strategies that protect plants from the negative impacts of drought includes drought escape, drought avoidance drought tolerance, breeding methods, transgenic approaches, Nano-biotechnology and Micro RNA. Thus, the majority of this review's attention is given to current findings about the morphological, physiological, biochemical and molecular responses and control mechanisms of rice under drought stress condition. Here, we additionally discussed about to how different molecular methods and tools may be used to increase rice's capacity to survive in drought condition.