Agricultural sustainability focus on developing environment friendly agronomic technologies and practices. Using chemical fertilizers and pesticides is an age-old agronomic practice to mitigate soil fertility problems and protect plants from pathogens and pests. These synthetic products are imposing hazardous effects on the environment and human health causing serious threats to agriculture sustainability. Incorporating biological, eco-friendly processes into agriculture and minimizing the use of environmentally harmful materials is the need of the day. The plant microbiome comprising of phyllosphere, rhizosphere and endosphere is inhabited by microorganisms. Researches on plant microbiome have brought to light that the microorganisms that are present in the rhizosphere and endosphere play a substantial role in improving the health and productivity of the host plant. The rhizospheric and endophytic bacteria are receiving much attention because of their plant growth-promoting attributes. These plant growth promoting bacteria (PGPB) enhance plant growth via direct and indirect mechanisms. The direct mechanism comprises phytostimulation (production of phytohormones, various signal and stress alleviating compounds) and biofertilization (Nitrogen fixation, nutrient acquisition, assimilation, iron sequestering). The indirect mechanism includes biocontrol (production of antibiotics, siderophore and bacteriocin, cell lytic enzymes, Cyanide biosynthesis and induction of systemic resistance genes). Plant growth-promoting rhizospheric and endophytic bacteria fit in the role of biofertilizers, biostimulator, and biopesticides, possessing the functional potential to replace chemical fertilizers and pesticides. These PGPBs can contribute significantly to agriculture sustainability by minimizing environmentally harmful activities.