Epidemiology of head injury has been often neglected with very few epidemiological studies pertaining to head injury especially in the state of Kerala, India. Unlike developed countries, there is no well-established system for collecting and managing information on TBI in Kerala, India. The aim of the present study is to provide a one-year base line data of the clinical, demographic profile as well as outcome in patients who sustained head injury in a tertiary care center in Kerala. The data from this study would definitely guide future experimental operational research for developing an electronic registry for head injury in Kerala. Methodology One-year retrospective descriptive observational study was done on head injury patients selected as per inclusion criteria attending Neurosurgery Department in aa tertiary care center in Kerala during 2019, Retrospective hospital-based data on demography, clinico etiological profile and outcome was collected and evaluated using descriptive statistics Results An average of 247 cases was admitted in hospital in the year 2019-20. Out of 112 patients investigated as per inclusion criteria in this study, 97 (87.5%) were males and 15 (12.5%) were females with mean age of 46.27± 15.03. years. 84 patients (75.8%) were addicted to alcohol.17 patients (15.6%) sustained severe head injury. Major cause of head injury was road traffic accident (N=89 patients (79.7%) Most of the injuries, 32 (28.9%) were bilateral, including both right and left hemispheres of brain. The mean duration of hospital stay study was 24 days ± 1.75 and the average cost of care was Rs. 35,000±2.62. Extremes of age were having a bad outcome in terms of Glasgow outcome score. Mortality rate in the present study was 10%. Conclusion This study is the first of its kind in Kerala highlighting the importance of maintaining a proper head injury registry. This study also identifies high risk groups for head injury and factors influencing clinical outcome which has definite implication in community-based rehabilitation. The data from this study would definitely guide future experimental operational research on these unexplored areas which will be relevant in health policy making in Kerala as well as in India.