Inorganic farming is an agriculture production method that involves the use of man-made products such as fertilizers, pesticides, herbicides. Soil health is the foundation of productive farming practices. Amaranthus hybridus L. (Green Amaranth) is widely used as a food plant and their leaves are nutritious. The major objective of the study is to evaluate the nutritional constituents of Amaranthus hybridus L. and heavy metal content in the plants cultivated in the agriculture field using chemical fertilizers. Also aims to assess the changes in soil physico-chemical characteristics after cultivation. A field study was conducted in the agricultural farm cultivating Amaranthus hybridus L. using inorganic fertilizers in the Pallichal Panchayath of Thiruvananthapuram district, Kerala, South India. Mature Amaranthus hybridus L. plants and soil samples were collected and analysed for various characteristics following standard procedures. The concentration of heavy metals in field soil samples and plant leaves were determined by Atomic Absorption Spectrometry (AAS), and evaluated its bioaccumulation factor. The results of present study revealed that the chemical fertilizer usage has enriched the field soils with macronutrients and also increased the nutrient and biochemical constituents in Amaranthus. Toxic heavy metals were detected in Amaranthus leaves, and are in the order: Cr>Zn>Pb. Prolonged consumption of leafy vegetables like Amaranthus with toxic heavy metals like lead and chromium, may lead to health problems in humans. The study recommends the eco-friendly cultivation of Amaranthus hybridus using organic manure and biopesticides to reduce heavy metal accumulation.