Background: Now a day’s cancer diagnosis is improvised on automated analysis at the background of consequences of malignant necrotic cell debris and fibrous materials in a scattered manner. Purpose: Epidemiology that is oriented to malignancies, based on its etiology, risk factors, diagnosis, prevention, and control subjected to cancer epidemiology on invasive pathogens. Materials and methods: This intense network of molecules, allowing communication among bacteria, viruses, and eukaryotic cells have evolved to guarantee optimal life in different ecological niches to each component of the ecosystem and is based upon effectors receptor for developing cancer. Results: The key role of this advanced part is the prior augmentation for systematic diagnosis as for cancer registry among the population. The particular research on epidemiological studies based on cancer diagnosis can be categorized as endemic based in a particular area (example: Northeast India) and as sporadic based on its frequently spreading in the world scenario. The epidemiological study on laboratory diagnosis of topographical cancer is designed by Pathology, Histopathology, Immuno-chemistry, Radiology, and Molecular genesis. Conclusion: So cancer is curable if preventive measures and controlling of risk factors can be done in the early stage of diagnosis at epidemiological reviewing on report analysis by an expert oncologist.