NDs have become a serious health problem to wide population of the world. Presently there is no cure available for most of the NDs. The current therapies for NDs focused on modifying the disease progression and symptoms. Nanometric drug delivery is a promising technique that can be employed to deliver the drug to the brain which can be accomplished through nasal cavity. Primary obstacle for the effective treatment of NDs is the presence of blood-brain barrier (BBB), which limits or prevents the drug from reaching the central nervous system (CNS). The development of nanotechnology through integrated multidisciplinary efforts, will result in novel insights into the functions of neural circuits and approaches for the diagnostic and therapy of brain diseases. The majority of nanotechnological drug delivery systems for the treatment of neurodegenerative diseases are in the form of polymeric nanoparticles. Polymeric nanoparticles can pass through the tight junctions, cross the BBB then achieve a high drug loading capacity and targeted the mutagenic proteins in neuro degenerative disease. This article discusses about the various neurodegenerative disorders, the method of targeting the diseases and the techniques to fabricate the formulations that can target the neuro-degenerative diseases.