Paracetamol in high dose has been proven to be hepatotoxic and paracetamol toxicity in man could occur accidentally in individuals that indulge in self-medication. The hepatoprotective effect of red palm oil against paracetamol induced hepatotoxicity was studied using twenty Swiss Wister rats which were divided into four groups of five rats each. The first group was the control group while the rest group were the experimental groups, group 3 and 4 were pretreated with 1ml and 2ml red palm oil respectively, however on the fifth day 3g/kg body weight of oral paracetamol was given to group 2, 3 and 4. The liver enzymes in the serum of the rats blood were assayed, there was no significance for ALT, while the AST level for the 2mL red palm oil was increased and the ALP level for the paracetamol induced hepatotoxicity group was higher compared to the rest of the groups, therefore the liver enzyme level for ALP shows that damage has been done to the liver due to increase activity of ALP in the serum of group two rats, which was prevented in group 3 and 4 that were also subjected to hepatotoxicity, however the liver histology indicates marked changes in the architecture of the liver between the groups. The control group show normal lobular architecture with well-preserved hepatic cell and central vein, which is also applied to group three and four except for slight central vein congestion in group four, while group two shows congested and dilated histological structure of central vein with Centro lobular necrosis in surrounding parenchyma. From the biochemical and histological studies it can be deduced that red palm oil has hepato-protective ability which could be attributed to it anti-oxidant content.