Introduction-Hepatitis B (HBV) and hepatitis C (HCV) viral infections are important causes of morbidity and mortality in haemodialysis patients and pose problems in the management of the patients in the renal dialysis units. Chronic renal failure patients do not clear these viral infections efficiently. Several outbreaks of hepatitis have occurred in these settings. Methods- This study was done in Sir-T Hospital from August, 2016 to September, 2016 to understand the prevalence of HBV and HCV infection among patient undergoing frequent Haemodialysis. The dialysis unit has 20 haemodialysis machines out of 6 machines exclusively used for known sero positive patients. Result-Total 2537 serum samples were tested for HBsAg testing and 1602 serum samples were tested for HCV testing; in which 125 samples were tested from the patients undergoing frequent dialysis due to chronic renal failure; out of which 18 [14.4%] samples were sero positive, in which 6 [33.3%] HBsAg was found positive; 12[66.7%] Anti HCV was found positive. In our study we have found 4 [22.2%] dual HBV & HCV infection. HBV infection is less prevalent than HCV in haemodialysis units. Conclusion-Significant immune status disturbances were registered in haemodialysis patients infected with both HBV and HCV compared to patients with HBV and HCV alone. The risk is greater among the CRF patients due to the frequent exposure to blood from transfusions and extracorporeal circulation during haemodialysis.