This chapter focuses on sustainable approaches to mosquito control, centering on using phytochemicals derived from plants. Mosquitoes, significant vectors of diseases worldwide, substantially threaten global health. The narrative emphasises the escalating challenges of vector-borne diseases, highlighting traditional synthetic insecticides' limitations and environmental concerns. It discusses the historical evolution of mosquito control methods, tracing the shift from botanical insecticides to the widespread use of synthetic chemicals. The central focus is on the potential of phytochemicals as effective tools in combatting mosquito-borne diseases, offering eco-friendly, cost-effective, and target-specific alternatives. The classification of secondary metabolites in plants, such as alkaloids, phenolics, and terpenoids, is explored, providing insights into the diverse mechanisms through which phytochemicals act against different stages of the mosquito life cycle. The narrative delves into phytochemical extraction techniques, emphasising their importance in preserving the natural structure of bioactive compounds. Challenges and opportunities in implementing phytochemical-based mosquito control are discussed, along with future prospects, recommendations, and the integration of these approaches into comprehensive mosquito management programs.