A zoonotic orthopoxvirus called human monkeypox has symptoms that resemble smallpox. New tests are required for a more accurate and quick diagnosis because laboratory diagnostics are key to illness identification and surveillance. Hope exists for the treatment and prevention of monkeypox thanks to new medications and vaccines. When people come into contact with diseased animals, they may unintentionally contract monkeypox. According to reports, the virus can also spread through close physical contact, such as skin-to-skin contact or sexual contact, respiratory droplets, and by household items like towels and blankets. It is a good idea to have a backup plan in case the backup plan fails. JYNNEOSTM (live, replication- incompetent vaccinia virus) and ACAM2000® are the two vaccines that are now available (live, replication competent vaccinia virus). Although supportive care is usually sufficient for most instances of monkeypox, which tend to be moderate and self-limited, there are antivirals (such as tecovirimat, Brincidofovir and cidofovir) and vaccinia immune globulin intravenous (VIGIV) that can be used as therapies. Antivirals should be taken into account in cases of severe illness, immunosuppressed individuals, children, pregnant and nursing women, complicated lesions, and when lesions develop close to the mouth, eyes, or genitalia. This quick review's goal is to give a brief description of each of these defences.