Pharmaceutical analysis involves the application of analytical chemistry techniques for the analysis of pharmaceutical compounds. It provides wide range of application involving determination of chemical structure of compounds, assaying of compounds, to test the purity and authenticity of compounds, determination of crystalline structure of compounds, determination of molecular weight and molecular formula of compounds and distinguish between isomers of compounds. This chapter discusses in detail the basic principle and applications of various pharmaceutical analysis techniques. The various analytical techniques includes the titrimetric methods, chromatographic methods, spectroscopic methods, diffractometeric techniques and thermal analysis techniques.