Natural chemical compounds released by sunflower leverages weed control by allelopathy in agricultural systems. Allelopathy refers to the biochemical interactions between plants, where one plant inhibits the growth of others through the release of allelochemicals into the environment. In this context, sunflowers, through their root exudates and decomposing residues, produce substances that can inhibit seed germination and seedling growth of various weed species. The main allelochemicals identified in sunflowers include phenolic acids, terpenoids, flavonoids, and sesquiterpene lactones. Allelochemicals like p-coumaric acid inhibits the germination and root elongation, Caffeic acid interferes with cellular respiration and protein synthesis, Ferulic acid disrupts the cell wall structure, Helianthin inhibits root growth, Germacrene D effects the root and shoot growth, Helianthus A inhibits cell division and elongation, Quercetin disrupts photosynthesis, Kaempferol inhibits enzyme activity, Rutin interferes with nutrient uptake, Heliolactone is a potent inhibitor of seed germination, Helianolide has inhibitory effect on the growth of weed roots and shoots, Helianthinolide inhibits the germination and early growth, Sunflower acid affects seed germination and early seedling growth. The allelopathic effects of sunflowers can reduce weed pressure in subsequent crops, leading to lower weed densities over time. Research into sunflower allelopathy aims to optimize these effects to enhance crop yield and reduce weed competition effectively. This natural weed management approach reduces the need for synthetic herbicides, offering a more sustainable and environmentally friendly alternative. Research is required to optimize the use of sunflower allelopathy in different agro-ecological contexts and to develop best management practices.