Plants and their products are nature’s gift to all humans and animals. They help them to lead a healthy, disease free life. Date plant is one of those natural product which is a good remedy in the treatment of many diseases and is affordable and effective without any adverse effects. The therapeutic value of the date palm plant is due to the presence of variety of bioactive and phytochemical compounds. In addition, being a good source of dietary fiber, dates are free from sodium, fat, and cholesterol, which makes them an appropriate dietary supplement for reducing the danger of heart diseases and cancer. Traditional systems of medicine use dates to treat a variety of ailments due to their antioxidant, antimicrobial, anti-inflammatory, anticancer, hepatoprotective, nephroprotective and immunostimulant activities as revealed by preclinical studies. Due to its nutritious and medicinal properties, the fruit of the date palm has been referred to as one of the most significant commercial crops and also been documented in Holy Quran and modern scientific literatures. This review provides an overview of the nutritional use and therapeutic value of date plant in treating various diseases.