Pomegranate is the “Crown Jewel” of the fruit world. It is a nutrient-rich fruit, which is being grown in tropical climate and has various restorative benefits due to bioactive compounds. It is now being applied in nutrition as well as medicinal manufacturing due to its strong possibilities. It has dominant nutritional values and vast health benefits. Pomegranate fruits, seeds and peels are thoroughly used in conventional medicine as a natural therapy. It contains overabundance of valuable ingredients like flavonoids, ellagitannin, punicalagin, ellagic acid, vitamins and minerals. The chief active constituents including punicalagin and ellagitannin are responsible for fathomless health benefits due to its strong antioxidant activity. The pomegranate, has since been used since remote ages in natural and integrated medicine therapies to treat sore throats, coughs, digestive disorders, urinary infections, skin disorders, arthritis and to debar tapeworms. The health benefits delineated globally recommended that pomegranates might be useful in medicating such serious conditions as different types of cancer, osteoarthritis, diabetes and Alzheimer. This can be because, pomegranates have the flexibility to thin the blood, increase blood flow to the gut, maintain blood pressure and plaque within the arteries and ability to reduce bad cholesterol while increasing good cholesterol. Pomegranate juice can lower C-reactive proteins and reduce the inflammation of the liver. Juice of flower is used to medicate nose bleeds. Research field in this area is expanding rapidly and gaining acceptance because of an perception of the fact that naturally accessible phytonutrients along with polyphenols and antioxidants put forward the convenient best security against many diseases and disorders. Pomegranates shields our body in a cellular level. The aim of this review was to present a profound thought of the multifunctional, nutraceutical, bioactive components and medicinal effects of pomegranate in countering various human disorders and human afflictions, has been duly encouraged by various researchers in medicine, nutrition, biochemistry, physiology and horticultural sciences.