Azadirachta indica A. Juss (Fam. Meliaceae; Subfam. Melioideae), commonly known as Neem, is an expeditiously growing tropical evergreen tree, traditionally known for its medicinal assets. For a millennium, agents extracted from natural sources, most importantly plants have been the key source of medicines. Neem is one of those plants that come up with all kinds of benefits. Neem is reckoned by many as "The village drugstore” due to its multitudinous medicinal properties. Consequently, these species are cultivated all over the world due to competition in trading and travel. It has come about capitalized in different medicinal methodologies Ayurveda, Unani, homoeopathy, therefore, expressed as the “epicentre” of modern medicine. It plays a huge role as a “health promoter” due to its rich source of antioxidants and boosts a person’s immunity. Neem and its components contribute a major role in eliminating disease pathogenesis. The essential bioactive secondary metabolites of Neem like Nimbin, azadirachtin, etc are comprehended for their immunomodulatory activity, effect against microbes, cancer cells, diabetes, obesity as well as anti-inflammatory, anti-hypertension, anti-hyperlipidaemia, effects. Each part of the neem tree from roots to its tip can be used as a shield for humans against different kinds of diseases. Neem leaves are known to be the natural source of isoprenoids, flavonoids, polyphenols and polysaccharides. Neem can be consumed orally or applied to the skin to cure several skin issues like pimples, rashes, allergies, and acne. It also lessens the symptoms of eczema, ringworm infection, and psoriasis. Additionally, its anti-cancer mechanism involves several molecular pathways, including NF-κB, PI3K/Akt, p53, pTEN, VEGF and Bcl-2. This plant underwent significant research to develop cost-efficient and harmless products. It is considered to be one of the safest medicinal plants and regulates several biological processes without causing unfavourable effects.