Datura stramonium commonly known as Dhatura or Jimson weed, is a herbaceous annual plant. It has been considered an asset of extensive pharmacological importance since ages. Folklore or traditional medicine's use of plant material as an indigenous remedy has led to the development of plant-derived drugs in contemporary medicine. The plant acts as an effective cure for a variety of ailments and is known therapeutic for parkinson's disease, cancer, asthma, gastric ulcers, rheumatism and bronchitis. Datura was also used as an anaesthetic in medical operations, to cure wounds, bruises, and haemorrhoids in ancient times. It grows wild within the tropical as well as temperate weather, however it's also found in the roadside vicinity along with the medicinal plant nursery. Datura is a source of 64 tropane alkaloid compounds with antioxidant potential. Saponins, flavonoids, alkaloids, glycosides, and phenol are found in abundance in the plant's crude aqueous and ethanol extracts. Scopolamine, a component of the plant, is a powerful cholinergic-blocking hallucinogen that has been used to treat schizoid individuals. Its leaves, which contain hyoscyamine and atropine, can be used as a highly effective mind-altering substance. However, confusion, hallucinations and subsequent amnesia are all symptoms of D. stramonium ingestion in excessive doses. Anxiety and delusions are associated with extreme abuse of Datura. It is lethal and can induce a variety of side effects.