Custard apple is one of the most delicious arid fruits known mostly for its dessert and confectionery values. Annona squamosa, which is one of the most widely grown species of Annona. Though rich in its nutritional aspects, it is an under-utilized arid zone crop. It has also been proved that the plant contains several medicinal properties which include antioxidant, anti-diabetic, anti-infective and anti dyslipidemic properties. The leaves are used as a vermicide, for treating cancerous tumors and are applied to abscesses, insect bites and other skin complaints. Scrapings of root-bark are used for toothache. This paper attempts to congregate the nutritional value, phytochemical composition, and medicinal uses of custard apple. The natural remedies and substitute medication have been used since early civilization for the treatment and wellbeing of human mankind. The medicinal plants are considered to be effective and for most important for the human health. Some of the natural medicinal plants are so common that we use them in daily life without knowing their medicinal importance. Annona squamosa belonging to the family Annonaceae is a well-known plant of natural niches is perceived as best example of it. It is a multipurpose saint tree with edible fruits. Its fruits are commonly known as etario of berries which is edible. The edible mass of custard apple is pulp entangled around the needs as sticky mass. The Vitamin C content is appreciable (35-42 mg/100 g) and slightly higher than in grapefruit. The nutrient value of thiamine, potassium and dietary fiber content is also significant. The custard apple is reported to possess various beneficial chemical compounds such as alkaloid, isomeric hydroxyl ketones from leaf, acetogenin, samaquasine, annonacin and annonastatin from seeds, acetogenin and squamone from bark of it. Various studies envisaged that custard apple possesses an antibacterial, antidiabetic, antitumor, antimalarial, anthelmintic, anti-genotoxic potential and hepatoprotective activity. The multifaceted uses of custard apple leaves include protein properties having vermicidal action for treating cancerous tumors, abscesses, insect bites and other skin diseases. The crushed leaves are sniffed in tribal areas to overcome the hysteria and fainting spells and they are also applied as medication for treatment of ulcers and wounds. Scrapings of root-bark are used for toothache. Powdered seeds are used to kill head-lice and fleas but excessive precaution should be taken that the powder does not come in contact with the eyes as this causes great pain. The crude extracts of different parts and pure isolated phytochemical constituents of custard apple fruit was reported to possess anti-diabetic, antiviral, antioxidant activity, respiratory stimulant, during pregnancy and diuretics properties being potent for the improvement of the immune system, nervous system and also for the development of the brain in the foetus. Custard apple can be the most effective available of choice among fruits for controlling various diseases and disorder and new paradigms in focusing the nutraceutical and valuable therapeutic potential will definitely help mankind to lead a disease free and healthy life.