The comprehensive and multipurpose medicinal properties of phytopharmacophores of the plants are basically reliant on their phytochemical constituents. Commonly, the plant phytopharmacophores ingredients are classified into two classes based on their role in basic metabolic phenomenon, namely primary and secondary metabolites. Primary metabolite is a kind of metabolite that is directly involved in normal life functions such as growth, development and reproduction of the plants. It generally accomplishes a physiological function in the organism. It is also discussed as a fundamental metabolite; therefore, they are more or less similar in all living organism of the plants. However, Secondary metabolites are ingredients that are not necessary for a cell organism to live, but play a vital role by the interaction of the cell organism with its environment. These constituents are regularly involved in plants protection against biotic or abiotic stresses. In the sequence of perusal, the pharmacophore effects of herbals are concerned with the secondary plant metabolites. Secondary plant metabolites played an important role in diminishing several ailments in the traditional pharmacophore and mutual uses. In series of contemporary pharmacophores, they provided central ingredients for the production of drugs for treating various ailments from minor up to heart attack, cancer etc. Secondary plant metabolites are categorized according to their chemical structures into various groups and sub groups. In this chapter, we will be proposing numerous classes of secondary plant metabolites, their dispersal in diverse plant families and their pharmacological applications.