Cancer is a major public health challenge. According to WHO 2020 report, 10 million death of people were listed as cancer. DNA damage triggered by ultraviolet radiations, environmental agents, ionizing radiations, etc. Almost all cancers are frequently diagnosed cancers are lung (12.7%), colorectal (9.7%), breast (10.9%), and gastric cancer (7.81%). Natural compounds are most favourable against cancer on their anti-cancerous ability, easy to avail and efficient. There is an urgent need for new effective anti-cancer drugs with fewer side effects, and plants show promising results for making drugs. In this chapter, we focus on some plant-derived drugs against cancer. These include 5-fluorouracil, artemisinin, polysaccharide, curcumin, etc. Also discussed uses and future prospects for the development of plant-derived substances with anti-cancer activity.