At present, challenges before the world to develop and maintain our available natural resources-based technologies specially related to drug discovery approaches in the context, over growth of population and over exploitation of natural resources. In India, the plants use in a therapeutic healing both traditionally and medicinally up to ancient periods. In Charak samhita, 340 drug origin from vegetable plants species used for the therapeutic treatments of human’s disease. The locally available plant has a much and more medicinal values we have collect these literatures and summarized in this type of plant and highlight their medicinal capacity and combinations for the recent approaches of drug discovery. Already isolated drug and their therapeutic combination shown in table-1, and in the table-2 shown various part of the plants use in treatments and table-3 shown various plants locally people use in antiviral activates recent Covid-19 pandemic duration, after that discovered have two vaccines, Covaxin and Covisheild to empirical cure or a vaccination for this potentially fatal disease. Mention traditional and current technical methods for recent approach plants drug design, highlight positioning and repurposing for drug and its outlines charts. The pharmacological uses of plants and diagrammatic shown the chemical structure of primitive and modern drug compound and molecules. The material is used for the study and research regarding fields.