Non-alcoholic fatty liver disease (NAFLD) is common cause of hepatic dysfunction. It is hepatic manifestation of metabolic disorder associated with obesity, insulin resistance and dyslipidaemia. It is a spectrum of liver disease, from a "bland" fatty infiltration to chronic hepatitis (steatohepatitis or NASH), that can result in cirrhosis, hepato cellular carcinoma and liver failure. The prevalence of fatty liver in India is 9-32% with an average of 25% in general population in India. If the disease progress then no pharmacological agent being officially approved to cure. Therefore, life style modification through diet control and exercise are the preventive ways. Evidence based Ayurveda medication for NAFLD are very acceptable by people now a day. Ayurveda treatment involves diet, yogic intervention, Panchakarma therapy and drug therapy. This review searched the Liver directed Ayurveda medication from accumulated evidences and literature which concluded that Liver directed Ayurveda medication are nothing but Yakrit uttejaka (liver stimulant), Pitta saraka (bile excreation), Sothagna (Anti-inflammatory) and pittghna (reduce bile production). The Ayurveda botanicals are katuki, kalmegha, Kumari, Daru haridra, Rohitaka, Apamarga root, Varuna, kakamachi Bringaraj etc. Virechana and Takra vasti have been practicing with good outcome. Ayurveda drug and Panchakarma can improve the hepatic lipid metabolism, stop hepatic lipogenesis, regulate the mitochondrial dysfunction, modulate lipid metabolism by bile synthesis, modulate the hepatic inflammation through apoptosis and autophagy, correction of gut bacterial composition. This accumulated evidences suggested for inclusion of Argya vardhini vati, Patolakaturohinyadi kasaya, Sharapankhadi churna, Rohitaka churna in current practice guidelines of NAFLD and encourage to generate more data for liver directed Ayurveda therapy in NAFLD.