The growing interest that bilayer tablets have sparked over the years, especially when it comes to the sequential delivery of two medicines with distinct release profiles. In order to improve comfort and compliance of patient, two-layers provide a workable way to achieve both immediate and sustained release of active pharmaceutical ingredients (APIs) in a single dosage form.The creation of bilayer tablets makes it possible to combine different APIs or include compounds that are incompatible with one another in a single tablet. The pharmaceutical industry's objective of enhancing therapeutic results and optimizing drug delivery is in line with this strategy. To overcome obstacles and guarantee high-quality production, a number of methods have been investigated for the manufacture of bilayer tablets. The review concludes by critically analyzing the difficulties involved in the manufacturing of bilayer tablets and offering solutions to these difficulties . The review concludes by focusing on advantages, disadvantages, properties, marketed formulations and GMP requirements of the Bilayer tablet.