Micelle-based hydrogels are advanced soft materials that have garnered significant attention for their multifunctional applications, especially in biomedicine. These hydrogels combine the structural properties of hydrophilic polymer networks with the dynamic assembly of micelles, which are nanoscale aggregates formed by amphiphilic molecules in aqueous environments. The integration of micelles into hydrogels enhances their mechanical strength, drug-loading capacity, and responsiveness to stimuli such as pH, temperature, or ionic strength. The chapter provides an in-depth exploration of the fundamental principles governing micelle-based hydrogels, including their self-assembly mechanisms, physicochemical properties, and structural dynamics. It delves into the design strategies used to tailor the performance of these materials, such as varying the polymer type, micelle-forming block copolymers, and crosslinking methods. The interplay between micelle stability and hydrogel properties is highlighted, demonstrating how it influences encapsulation efficiency and controlled release behavior. Applications of micelle-based hydrogels are discussed extensively, emphasizing their role in drug delivery systems, tissue engineering scaffolds, and bioimaging. Their unique ability to encapsulate hydrophobic and hydrophilic molecules enables targeted and sustained therapeutic delivery, minimizing side effects and improving efficacy.