Trisomy 18, also known as Edwards syndrome is the second most common trisomy among live-born fetuses. Most cases are prenatally diagnosed during the second and third trimester on screening by maternal age, maternal serum marker screening, or detection of sonographic abnormalities. We present a case of trisomy 18 diagnosed on ultrasound during the second trimester. The foremost feature to clinch the diagnosis of trisomy 18 in our case report was the presence of enlarged bilateral choroid plexus cysts. Additional structural abnormalities in our case report were, strawberry skull, cisternal magna, prenasal thickening, low set ears, cardiomegaly with membranous VSD, bilateral persistent clenched fingers, right hydronephrosis, and bilateral rocker bottom foot. In presence of enlarged bilateral choroid plexus cysts search for additional structural malformations should be encouraged as they are a significant risk factor and also an indication for the determination of fetal karyotype.