Virus induced gene silencing (VIGS) is an efficient technology that exploits RNA-mediated antiviral mechanism in plants. VIGS is rapid, efficient and specific system targeted against the viral genome. To counteract plant’s anti-viral defense viruses are evolved with mechanisms by expressing with viral suppressors of RNA silencing. Besides working as silencing suppressors these genes also aid in virus infection. In this review we summarize the current status of knowledge about the diverse viral suppressor genes and how they act at various steps of antiviral silencing in plants. Finally we present the current applications and discuss the perspectives of the use of silencing suppressors in molecular biology and biotechnology.