Fungicides or nematicides use have been dominated the plant protection strategies over the years. But due to its excessive use and harmful effects on environment and even humans, there is a need of practicing biological control for plant disease management. Biological control is a natural control that maintains a natural balance between plant pathogenic microbes and beneficial microbes by checking the growth of harmful plant pathogens by exploiting beneficial biological control agents or antagonist against them and thus managing the plant diseases. Biological control refers to the suppression of one organism (or pest) by another organism (antagonist). Biological control operates through various mode of actions like: Competition, Parasitism, Antibiosis, Lytic enzymes and induced systemic resistance (ISR). Most commonly exploited biocontrol agents are Trichoderma, Pseudomonas and Bacillus used against a number of Plant diseases.