A wide range of potentially pathogenic microbes are found in the environment of plants. Nevertheless, plants are able to resist the great majority of microbes they encounter and are susceptible to only a small number of specifically adapted pathogens. Capacity of a plant to defend the invading pathogens depends on the various signalling events produced by the different kind of signaling molecules including fatty acids and lipids. Fatty acids (FAs) and lipids, which are major and essential constituents of all plant cells, not only provide structural integrity and energy for various metabolic processes but can also function as signal transduction mediators. Lipids and FAs can act as both intracellular and extracellular signals. In addition, cyclic and acyclic products generated during FA metabolism can also function as important chemical signals (Lim et al., 2017).