Cholelithiasis is derived from the Greek word chol means "bile" + lith means "stone". Presence of stones in the gallbladder is referred to as cholelithiasis. Bile consists of water, electrolytes, bile acids, cholesterol, phospholipids and conjugated bilirubin. Bile is secreted by the liver into small ducts that join to form the common hepatic duct and get stored in gall bladder. Gallstones may be silent, producing no pain & only mild gastrointestinal symptoms. Such stones may be detected incidentally during surgery or evaluation for untreated problems. Epigastric distress, Feeling of Fullness, Abdominal distention, Vague pain in the right upper quadrant of the abdomen, Distress may follow a meal high in fried or fatty foods, Pain and biliary colic. Assessment & Diagnostic Findings: -Abdominal ultrasound. Ultrasonography (USG), Radionuclide imaging or cholescintigraphy or HIDA (Hydroxyiminodiacetic acid scan), Cholecystography, Endoscopic retrograde cholangiopancreatography (ERCP), Percutaneous transhepatic cholangiography (PTC), CT (computerised tomography) scan and MRI (Magnetic resonance imaging). Management of cholelithiasis: Nutritional & supportive therapy, Pharmacologic therapy, Nonsurgical removal, Surgical management.