Advanced Research and Case Reports in Medical Science and Health (Volume - 1), edited by Dr. Ajay Kumar Reddy Bobba, offers a compelling exploration into critical topics at the forefront of modern healthcare. This volume brings together eight evidence-based chapters focusing on key themes such as cryokinetics in rehabilitation, innovative pharmacological interventions for chronic heart failure, and the intersection of polycrisis—poverty, political instability, and environmental degradation—and its impact on global health. It also includes practical insights on cholelithiasis, diffuse midline glioma, splenectomy, headache disorders, and infertility. With contributions from scholars, clinicians, and medical experts, the book bridges clinical understanding with social health challenges, making it relevant for researchers, educators, practitioners, and policymakers. Each chapter not only advances medical knowledge but also addresses pressing public health issues through a multidisciplinary lens, making this volume a valuable reference for navigating the complexities of contemporary medical practice and healthcare delivery systems.