Headache is a sensation of pain in any region of head and which may range from sharp pain to dull pain. It is a very common symptom. It can occur on one side or both sides of the head. Headache was defined as recurrent (two or more) primary episodes of pain in the head area, not secondary to any initial organic disease and, when occurring, experienced as disturbing daily life during the preceding six months. These are not caused by underlying diseases or any structural problems. These are benign, recurrent headaches. About 90% of headaches are of primary type. They usually first occur at the age of 20 to 40 yrs. Vasodilation of intracranial extra cerebral blood vessels (possibly the result of an imbalance in the brainstem) results in the activation of the perivascular trigeminal nerves that release vasoactive neuropeptides to promote neurogenic inflammation. Central pain transmission may activate other brainstem nuclei, resulting in associated symptoms (nausea, vomiting, photophobia and phonophobia).